A 25 years old female was having fever and
weight loss for a period of six months.
Her blood picture showed the leukemic picture. A bone marrow transplantation was
decided. The leukocyte count was normal
after transplantation. The chromosomal
analysis of her blood cells showed 46 XY chromosomes. What is the most probable cuause of this
finding?
- Angleman syndrome
- Klinefelter syndrome
- Pseudohermaphroditism
- The blood WBCs are derived from a male bone marrow
- Turner syndrome
Answer:d
Explanation:
The patient own marrow cells are destroyed before bone
marrow transplantation. The donor cells
proliferate and if the donor is male in this case then the blood cell WBCs are
of a male karyotype 46XY.
(Choice a) In
Angelman syndrome there is uniparental disomy of parental chromosome 15.
(Choice b) In
Klinefelter syndrome the kayotype is mostly 47 XXY. There is male hypogonadism.
(Choice c) In
Pseudohermaphroditism there is androgen insensitivity.
(Choice e) In
Turner syndrome the Karotype is 45X.
Educational
Objective:
In bone marrow transplantation the blood WBCs are coming
from donor marrow which has its own karyotype that is different from the other
cells of the person.
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